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miércoles, 8 de diciembre 2021
08/12/2021
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Research group

Spanish

Cellular Immunology and Immunogenetics Group

Academic Unit: Faculty of Medicine

Colombian Ministry of Science

Class

A1

Call

833

Profile

OECD

Discipline

Medical and health sciences

Subdiscipline

Clinical medicine

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Strategic Focus

The research approach has been strengthened through omic studies and the use of different bioinformatic approaches, including transcriptomics (RNA-seq, microarrays), metabolomics (metabolic reconstruction from genome and transcriptome, metabolic flow analysis), and a minor approach to genomics (sequencing of mycobacterial genomes, possibility of exomic analysis).

To be able to understand the mechanisms of pathogenicity of different Mtb strains and the progression and severity of the disease

Research Areas and Topics

  • Autoimmunity.
  • Transplant Immunology.
  • Immune response in tuberculosis.

Sustainable Development Goals (SDGs)

Good health and well-being  Quality Education Affordable and clean energy Partnerships for the goals

Group Coordinator

Mauricio Rojas López, PhD

PhD in Immunology

Universidad de Antioquia.

Group Coordinator Email

mauricio.rojas@udea.edu.co

Research Group Email

grupogicig@udea.edu.co

Scientific Cooperation

Collaborative Relationships

Local:

  • The National Center of Genomic Sequencing (CNSG).
  • the Bioprocesses Group, and the Embedded Systems and Computational Intelligence Group SISTEMIC, both from the School of Engineering.
  • the Epidemiology Group GEPI from the National School of Public Health.
  • Primary Immunodeficiencies Group, from the School of Medicine.

International:

  • Larry Schlesinger and Wolfgang Sadee, Ohio State University, United States of America.
  • Tom HM Ottenhoff, Leiden University, Netherlands.
  • Erwin Schurr, McGill University, Canada.

Notable Projects

  • A project that seeks to establish the role of sRNA mcr11 in Colombian clinical isolates of mtb through the use of the CRISPRi-Cas9 technique.
  • Detection of inflammatory metabolites and mycobacterial products in human respiratory exhalations of paucibacillary tuberculosis patients and children with TB using chromatographic techniques.
  • Polymeric Nanoparticles in conjunction with mannose and lectins for the encapsulation of selective inhibitors of the Janus kinases directed towards monocytes for the alternative treatment of autoimmunities.
  • Functionalization of magnetic oxide nanoparticles through monocytes as a potential tool to track tissue damage in vivo.

Main Research Results

  • Infection of monocytes from tuberculosis patients with two virulent clinical isolates of Mycobacterium tuberculosis induces alterations in myeloid effector functions. Sometido a Frontiers Cell Infect Microbiol. DOI: 10.3389/fcimb.2020.00163
  • Human alveolar and splenic macrophage populations dis play a distinct transcriptomic response to infection with Mycobacterium tuberculosis. Sometido a Frontiers in Immunology. DOI: 10.3389/fimmu.2020.00630
  • A systematic evaluation of Mycobacterium tuberculosisGenome-Scale Metabolic Networks. DOI: 10.1371/journal.pcbi.1007533

Research Portafolio

Services offered by the Transplant Immunology Laboratory:

  • HLA-A, B, C, DRB1, DQA and DQB classification by PCR-SSP and PCR-SSO (Under the Luminex platform) 
  • ABO and RhD blood group classification
  • Alloantibody study by cytotoxicity
  • Alloantibody study by flow cytometry
  • Qualitative, quantitative, and single antigen panel reactivity study (PRA)

more information

More Information

https://bit.ly/2wawmSW

 
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