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domingo, 28 de noviembre 2021
28/11/2021
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Research group

Spanish

Immunomodulation Group

Academic Unit: Faculty of Medicine,  Academic Corporation for the study of Tropical Pathologies

Colombian Ministry of Science

Class

A

Call

833

Profile

OECD

Discipline

Natural sciences

Subdiscipline

Biological sciences

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Strategic Focus

The group researches chronic inflammatory diseases. It uses animal models (mainly mice) of infectious chronic (e.g., cutaneous Leishmaniasis), allergic (e.g., allergic asthma), metabolic (such as atherosclerosis and diet-induced obesity), and autoimmune (such as multiple sclerosis and Psoriasis) inflammation. Such models are used to research basic aspects of the disease and as a platform for the preclinical development of vaccines, immunotherapies, and other measures of prophylactic and therapeutic interventions.

Research Areas and Topics

  • Immune modulation in atherosclerosis.
  • Immune modulation in allergic inflammation of airways.
  • Immune modulation in leishmaniasis.
  • Immune modulation in autoimmunity.

Sustainable Development Goals (SDGs)

Good health and well-being

Group Coordinator

José Robinson Ramírez Pineda, Ph

PhD in Immunomodulation

University of Würzburg.

Group Coordinator Email

jrobinson.ramirez@udea.edu.co

Research Group Email

grupoinmunomodulacion@udea.edu.co

Scientific Cooperation

Collaborative Relationships

  • Coloides- Bioactive Substances (GISB).
  • GICIG.
     
  • Vidarium (Grupo Nutresa).
  • Nexentia (Spin-off UdeA).

Notable Projects

  • Preclinical development of a molecularly defined liposomal vaccine for cutaneous leishmaniasis.
  • Concept testing of a nanoimmunotherapy prototype for cardiovascular diseases and other chronic non-transmissible conditions.
  • Immune modulation of atherosclerosis and diet-induced obesity through nutritional intervention with green coffee extracts.

Main Research Results

  • Reformulating Small Molecules for Cardiovascular Disease Immune Intervention: Low-Dose Combined Vitamin D/Dexamethasone Promotes IL-10 Production and Atheroprotection in Dyslipidemic Mice. DOI: 10.3389/fimmu.2020.00743
  • Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice. DOI: 10.3390/nu11030497
  • Genomic Analysis of Colombian Leishmania panamensis strains with different level of virulence. DOI: 10.1038/s41598-018-35778-6
  • Biflavonoids Modulate Macrophage–Oxidized LDL Interaction In Vitro and Promote Atheroprotection In Vivo. DOI: 10.3389/fimmu.2017.00923

Research Portafolio

  • Formulation and characterization of vaccines and immunotherapies based on liposomes.
  • Preclinical prophylactic and/or therapeutic evaluation in preclinical models (mice) of cutaneous leishmaniasis, allergic asthma, atherosclerosis, diet-induced obesity, psoriasis, and experimental autoimmune encephalomyelitis.
  • Use of mice as experimental models of human and veterinary disease.

More information

More Information

https://bit.ly/2ZbB0uD

 
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