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martes, 7 de diciembre 2021
07/12/2021
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Research group

Spanish

Cellular and Molecular Biology CIB

Academic Unit: Faculty of Medicine

Colombian Ministry of Science

Class

A1

Call

833

Profile

OECD

Discipline

Medical and health sciences

Subdiscipline

Clinical medicine

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Strategic Focus

Understanding the cellular biology of pathogenic fungi using molecular tools and computational biology.

Evaluation of potential drugs for human use.

Classification of fungi of the genus Aspergillus using classic taxonomy and complete genome sequencing.

Assessment of the presence of possible genes involved in allergic processes and antimicrobial resistance.

Study of cardiovascular diseases using molecular tools.

Research Areas and Topics

  • Bioinformatics.
  • Molecular biology of mycosis.
  • Hypertension and cardiovascular risk.
  • Microbiology and biotechnology.

Sustainable Development Goals (SDGs)

Climate action Partnerships for the goals

Group Coordinator

Orville Hernández Ruiz PhD

PhD in Biology

Universidad de Antioquia, Colombia.

Group Coordinator Email

orville.hernandez@udea.edu.co

Scientific Cooperation

Collaborative Relationships

  • Corporation for Biological Research.
  • Universidad del Rosario, Colombia.
  • Federal University of Goiás, Brazil.
  • North Carolina University, United States of America.
  • Institución Universitaria Colegio Mayor de Antioquia.
  • Tecnoquímicas.

Notable Projects

  • Morphological characterization, molecular tipification, and evaluation of the expression of genes involved in the resistance and allergenic protein production of Aspergillus species isolated from in-hospital and out-of-hospital environments in the Aburrá Valley metropolitan area.
  • Implementation of the CRISPR/Cas9 System for gene editing in fungal pathogens.
  • Concordance between the estimated biological age with a clinical cardiovascular algorithm and a biomarker-based method.
  • E. coli expression of Reteplase, a variant of recombinant Human Plasminogen Tissue Activator.

Main Research Results

  • Draft Genome Sequences of Clinical and Environmental Isolates of Aspergillus tamarii from Colombia. DOI: 10.1128/MRA.01514-19
  • Updates and Comparative Analysis of the Mitochondrial Genomes of Paracoccidioides spp. Using Oxford Nanopore MinION Sequencing. https://doi.org/10.3389/fmicb.2020.01751
  • Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi. ISSN 2045-2322. DOI: 10.1038/s41598-018-22816-6
  • Molecular Epidemiology of Candida auris in Colombia Reveals a Highly Related, Countrywide Colonization With Regional Patterns in Amphotericin B Resistance. DOI: 10.1093/cid/ciy411

Research Portafolio

 

  • Technical services for the assessment of possible molecules or antimicrobial drugs, mainly for fungi and bacteria.
  • Expert advice on bioinformatic analysis (microorganisms).

More Information

https://bit.ly/33yIuea

 
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