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martes, 7 de diciembre 2021
07/12/2021
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Research group

Spanish

Structural Biochemistry of Macromolecules Group

Academic Unit: Faculty of Exact and Natural Sciences

Colombian Ministry of Science

Class

A

Call

833

Profile

OECD

Discipline

Natural sciences

Subdiscipline

Chemical sciences

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Strategic Focus

The group has the objective of investigating peptides with antimicrobial activity and peptides with activity against cancer cells. It also aims to purify proteins such as human BMP-2 for developing bone tissue, human IL-4, and IL-5 for building biosensors. The group uses chemical synthesis and recombinant DNA to obtain peptides and human proteins, correspondingly. The goal is to conduct primary research to understand antibacterial resistance, cancer physiology, tissue development, and cytokine detection.

Research Areas and Topics

  • Membrane Biophysics.
  • Chemical Physiology.
  • Antimicrobial Peptides.

Sustainable Development Goals (SDGs)

Group Coordinator

Edwin Bairon Patiño González, Ph.D.

Ph.D.

Julius Maximilian University of Würzburg (Germany).

Group Coordinator Email

edwin.patino@udea.edu.co

Scientific Cooperation

Collaborative Relationships

  • Jagiellonian University (Poland).                                                                               
  • Universidad de los Andes (Colombia).
  • Universidad Nacional de Colombia.
  • Universidad Industrial de Santander (UIS; Colombia).
  • Tandem Group in Nanobioengineering — UdeA.
  • National Center for Genomic Sequencing — UdeA.
  • AM Ltda. (private company).

Notable Projects

  • Snake-derived peptides as a therapeutic strategy in the treatment of breast cancer.
  • Design of a liposomal formulation of bioactive peptides as a strategy to improve selectivity of antitumoral treatments in skin cancer.
  • Electrochemical biosensor to measure IL-5 in serum: an approach to the diagnosis of Hypereosinophilic and Churg-Strauss syndromes.
  • Biosynthesis of the human inductor of bone tissue formation in Escherichia coli bacteria.

Main Research Results

  • Result 1: Increasing the peptide load favored the interaction with the bacterial membrane and its disturbance, which increased the antimicrobial activity of the peptide.
  • Result 2: The peptides synthesized from a model peptide altered the temperature of transition of membranes.
  • Result 3: The immunological challenge of Leishmania parasites induces production of peptides with antiparasitic activity.
  • Result 4: Diminution on cellular viability after treatment with the LTX-315 peptide.

Research Portafolio

  • FTIR analysis.
  • Protein purification through chromatography.
  • Lyophilization.
  • Bacterial capacitation through rbcL.
  • Chromatography of SDS-PAGE and agarose.
  • Ultra-concentration of proteins through the Amicon system.

More Information

https://bit.ly/31zDS6l

 
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