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As part of the Master Class UdeA program: local talent at the service of global causes, we present the Master Class entitled: "Natural products for cancer chemoprevention".  This class focuses on the thematic axis Biotechnology, Bioeconomy and Environment. It addresses one of the main public health problems worldwide.

Cancer is a multifactorial disease influenced by both heredity and the environment.  According to the WHO, it is the second leading cause of death globally. Despite advances in early diagnosis and therapy, it is still detected and treated in advanced stages.  There is a large body of epidemiological and experimental evidence supporting the idea that certain dietary modulatory factors (bioactive compounds) play a key role in cancer prevention.

This Master Class will address prevention and chemoprevention strategies through dietary changes and the use of bioactive compounds in fruits and vegetables.  The importance of Colombian food and biodiversity as a potential source of natural products to combat certain types of cancer will be discussed.  Besides, the growing demand from health-conscious consumers has driven the market for functional foods with chemopreventive properties.  Therefore, it is critical to understand and take advantage of Colombia's biodiversity to identify and evaluate bioactive compounds in plant foods, with the goal of developing cancer chemopreventive products.  This Master Class is aligned with the strategic lines of Biointelligent Colombia, Health and Wellness of the Bioeconomy mission.

It is aimed at practitioners and students of biological and health sciences who wish to broaden their knowledge of the chemopreventive properties of natural products from Colombian biodiversity against cancer.  

Biography:

María Elena Maldonado Celis has been a professor at the Universidad de Antioquia since 2005. She holds a degree in Biology from Universidad Simón Bolívar in Venezuela.  Specialist in Biochemistry from Universidad de Antioquia. Master in Basic Biomedical Sciences from Universidad de Antioquia. PhD in Life and Health Sciences from the University of Strasbourg, France.  Senior Researcher in the Research Group Impact of Food Components on Health.

Complementary academic material:   

Research articles    

• Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon. http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0004-06222014000100003  
• Mango de azúcar (Mangifera indica), variedad de Colombia: características antioxidantes, nutricionales y sensoriales. https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182014000300013  
• Comparative Antioxidant, Antiproliferative and Apoptotic Effects of Ilex laurina and Ilex paraguariensis on Colon Cancer. Cells. http://dx.doi.org/10.4314/tjpr.v13i8.12  
• Características nutricionales y antioxidantes de la fruta curuba larga (Passiflora mollissima Bailey). http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-41082014000200007  
• Propiedades quimiopreventivas del mango y la manzana en el cáncer de colon. https://www.siicsalud.com/des/expertoimpreso.php/128728  
• Differential Induction of Apoptosis by Apple Procyanidins in TRAIL-Sensitive Human Colon Tumor Cells and Derived TRAIL-Resistant Metastatic Cells. https://bibliotecadigital.udea.edu.co/handle/10495/21982.  
• Apple procyanidins activate apoptotic signaling pathway in human colon adenocarcinoma cells by a lipid-raft independent mechanism. https://doi.org/10.1016/j.bbrc.2009.08.016.  
• Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells. https://doi.org/10.7705/biomedica.v30i4.296  
• Antioxidant and antiproliferative activity of ethanolic and aqueous extracts from leaves and fruits juice Passiflora edulis. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-41082013000100001  
• Modulation by polyamines of apoptotic pathways triggered by procyanidins in human metastatic SW620 cells. https://link.springer.com/article/10.1007/s00018-008-8023-4  
• PRO-APOPTOTIC EFFECTS OF APPLE PROCYANIDINS IN HUMAN COLON CANCER CELLS AND THEIR DERIVED METASTATIC CELLS. https://revistas.udea.edu.co/index.php/vitae/article/view/7443/6867  
• Extracto acuoso de uchuva (Physalis peruviana): actividades antiproliferativa, apoptótica y antioxidante. http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0124-41082013000100003  
• Bioactive Compounds from Andean Berry (Vaccinium meridio-nale Swartz) Juice Inhibited Cell Viability and Proliferation from SW480 and SW620 Human Colon Adenocarcinoma Cells. https://sciforum.net/event/Foods2022.  
• Frutas en la prevención del Cáncer. https://issuu.com/cristiantoro/docs/revista12  
• Propiedades antioxidantes de extractos de curuba (Passiflora mollisima Bailey) en crema de leche. https://revistas.udea.edu.co/index.php/nutricion/article/view/23445  
• Colorrectal cancer chemopreventive properties of Passiflora mollissima (Kunth) L. H. Bailey (banana passion fruit). https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDREVISTA=262&IDARTICULO=60522&IDPUBLICACION=5988  
• Características nutricionales y antioxidantes de la uchuva colombiana (Physalys peruviana L.) en tres estadios de su maduración. https://www.alanrevista.org/ediciones/2015/4/art-6/  
• Antioxidant and cytotoxic activity of black and Green tea from Vaccinium meridionale Swartz leaves. https://doi.org/10.5897/JMPR2014.5744  
• Behavior of bioactive compounds and antioxidant activity of mango (Azucar cultivar) juice during storage at 4 ºC. https://doi.org/10.15446/rfnam.v72n1.72628   
• Cytotoxic effect and antioxidant activity of Andean berry (Vaccinium meridionale Sw) wine. https://doi.org/10.5897/JMPR2016.6100  
• Impact of Colombian yellow fruits and tropical fruits drinks consumption on the antioxidant status of healthy women. https://doi.org/10.5897/JMPR2016.6146  
• Efecto del tiempo de almacenamiento sobre las características fisicoquímicas, antioxidantes y antiproliferativa de néctar de agraz (Vaccinium meridionale Swartz. https://www.alanrevista.org/ediciones/2016/4/art-1/  
• Mango (Mangifera indica cv. Azúcar) antiinflammatory and chemopreventive role during colorectal carcinogénesis. https://www.ejfa.me/index.php/journal/article/view/1316/973  

Book chapters    

• The Contribution of Fruit and Vegetable Consumption to Human Health. https://doi.org/10.1002/9781119158042.ch1  
• Andean Berry (Vaccinium meridionale Swartz). https://doi.org/10.1002/9781119158042.ch40  
• Coffee, Ginger and Cinnamon. https://doi.org/10.1002/9781119804055.ch12   

Booklets   

• Fitonutrientes derivados de palma africana, sacha inchi y macadamia. https://www.sic.gov.co/boletines-tecnologicos/fitonutrientes-derivados-de-la-palma-africana-sacha-inchi-y-macadamia  
• Descripción, características y beneficios de Passiflora edulis: parchita, fruto de la pasión, maracuyá. http://hdl.handle.net/20.500.11912/9567  

Videos    

• Pregunta y verás: ¿Mango maduro o mango biche? https://www.youtube.com/watch?v=8J366zQt7RY&list=PL_HkC8-huRmgq8vw327GMRChoj3RxTmx6&index=10  
• Crear Tiene Ingenio (CT+I), en el capítulo "Los Antioxidantes”.  https://www.youtube.com/watch?v=ZO9zyHrpSKE&t=16s   

Additional material:   

Keywords:  

Food, biodiversity, cancer, global, chemoprevention, health, Colombia.    

CVLAC:    

https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000140767     

Contact information:   

maria.maldonado@udea.edu.co