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sábado, 27 de noviembre 2021
27/11/2021
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Research group

Spanish

Genetics, Regeneration and Cancer

Academic Unit: Faculty of Exact and Natural Sciences

Colombian Ministry of Science

Class

A1

Call

833

Profile

OECD

Discipline

Natural sciences

Subdiscipline

Biological sciences

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Strategic Focus

To identify the molecular and cellular mechanisms that are involved in cancer and regeneration processes in order to contribute to the transfer of knowledge and technology to develop regenerative medicine therapies for humans.

Research Areas and Topics

  • Occupational genotoxicology in populations exposed to industrial carcinogens in Cerro Matoso S.A. and Ecopetrol.
  • Microbial genetics.
  • Population genetics.
  • Toxicological genetics and environmental mutacarcinogenesis.
  • Tumor genetics.
  • Regenerative medicine.
  • Genetically modified microorganisms.
  • Analysis on the X chromosome inactivation and its relation to breast cancer.
  • Regenerative biology.
  • Cell cycle.
  • Cytogenetics and anti-cytostatic agents in leukemoid cells.
  • DNA damage, repair and oxidative stress.
  • Molecular diagnosis in humans.
  • Molecular epidemiology of Streptococcus pneumoniae.
  • Susceptibility genes in gastrointestinal cancer.

Sustainable Development Goals (SDGs)

Group Coordinator

Jean Paul Delgado Charris, Ph.D.

Post-doctorate in Molecular Biology.

University College London.

Group Coordinator Email

jean.delgado@udea.edu.co

Scientific Cooperation

Collaborative Relationships

  • Universidad EAFIT, Colombia.
  • Universidad CES, Colombia.
  • The University of Kentucky, USA.
  • Jackson Laboratories, USA.
  • Karolinska Institute.
  • Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Notable Projects

  • Identifying molecules with anti-cancer and regenerative potential from Colombian biodiversity amphibians.
  • Creation of transgenic salamanders to elucidate regenerative mechanisms such as the loss of a limb.
  • Molecular biomonitoring of the genotoxic damage caused by pollution from the Aburra Valley.
  • Description of the regenerative process in Colombian salamanders.
  • Creation of molecular databases from technological amphibians.

Main Research Results

  • Identifying peptides with antimicrobial and anti-cancer potential from Colombian frogs and salamanders. 
  • Description of regenerative processes on a morphological and cellular level in Colombian salamanders.
  • Creation of molecular databases from Colombian salamanders.
  • Creation of the first transgenic vertebrate in Colombia.

Research Portafolio

  • Cell cycle analysis
  • Analysis of proliferation, cytotoxicity, and apoptosis.
  • Analysis on the effect of drugs and natural or semi-synthetic compounds.
  • Isolation of tissue cell lines or tumors.
  • Cytogenetics description and cell lines karyotypes.
  • Occupational cytogenetic biomonitoring (mining, refinery, etc.).
  • Analysis of the toxicity and genetic effect of drugs and natural or semi-synthetic compounds.
  • Citogenotoxicity test for bioactive substances and cosmetics.
  • Analysis on oxidative stress in blood cells and cell lines.
  • Cytogenetic test on micronucleus.
  • In vivo micronucleus test through flow cytometry.
  • Chromatid exchange test for alkylating agents or cross-linking agents.

More Information

https://bit.ly/383bM5x

 
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